nTRD22 | TDP-43-RNA inhibitor | Probechem Biochemicals

Chemical Structure : nTRD22

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nTRD22 (TDP-43 inhibitor nTRD22)

货号: PC-73021Not For Human Use, Lab Use Only.

nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.

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生物&药学活性

nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.
nTRD22 likely elicits TDP-43 phase separation and TDP-43 degradation by blocking RNA binding.
nTRD22 mitigates motor defects in a Drosophila model of ALS overexpressing TDP-43.

物理化学性质&存储条件

分子量	413.397
分子式	C19H22F3N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(3-hydroxypiperidin-1-yl)ethyl)-5-((3-(trifluoromethyl)phenoxy)methyl)isoxazole-3-carboxamide

参考文献

1. Mollasalehi N, et al. ACS Chem Biol. 2020 Nov 20;15(11):2854-2859.

nTRD22 (TDP-43 inhibitor nTRD22)

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物理化学性质&存储条件

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nTRD22 (TDP-43 inhibitor nTRD22)

生物&药学活性

物理化学性质&存储条件

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