nNOS inhibitor 17

Chemical Structure : nNOS inhibitor 17

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货号: PC-20973Not For Human Use, Lab Use Only.

nNOS inhibitor 17 is a potent, selective neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 15 and 19 nM for rat and human nNOS, respectively.

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生物&药学活性

nNOS inhibitor 17 is a potent, selective neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 15 and 19 nM for rat and human nNOS, respectively.
nNOS inhibitor 17 displays 1075-fold selectivity over human eNOS and 115-fold selectivity over human iNOS.
nNOS inhibitor 17 displays excellent cell-membrane permeability along with significantly low P-gp and BCRP substrate liability.

物理化学性质&存储条件

分子量	319.40
分子式	C18H23F2N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	NC1=NC(CCC2=CC(CCN(C)C)=CC(F)=C2F)=CC(C)=C1

参考文献

1. Vasu D, et al. J Med Chem. 2023 Jul 11. doi: 10.1021/acs.jmedchem.3c00782.