msR4M-L1 | Probechem Biochemicals

Chemical Structure : msR4M-L1

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msR4M-L1 (MIF-specific human CXCR4 mimic-ECL1[97-110]-6-Ahx-12-Ado-ECL2[182-196])

货号: PC-38320Not For Human Use, Lab Use Only.

msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to MIF (KD<40 nM) but not CXCL12 (>140-fold selectivity).

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100 mg		Get quote

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生物&药学活性

msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to migration inhibitory factor (MIF) (KD<40 nM) but not CXCL12 (>140-fold selectivity)。
msR4M-L1 has potency compares well with established MIF inhibitors, whereas msR4M-L1 does not interfere with cardioprotective MIF/CD74 signaling.
msR4M-L1 enriches in atherosclerotic plaques, blocks arterial leukocyte adhesion, and inhibits atherosclerosis and inflammation in hyperlipidemic Apoe-/- mice in vivo.
msR4M-L1 has the full name as "MIF-specific human CXCR4 mimic-ECL1[97–110]-6-Ahx-12-Ado-ECL2[182–196].

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	MIF-specific human CXCR4 mimic-ECL1[97-110]-6-Ahx-12-Ado-ECL2[182-196]

参考文献

1. Christos Kontos, et al. Nat Commun. 2020 Nov 25;11(1):5981.

msR4M-L1 (MIF-specific human CXCR4 mimic-ECL1[97-110]-6-Ahx-12-Ado-ECL2[182-196])

生物&药学活性

物理化学性质&存储条件

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msR4M-L1 (MIF-specific human CXCR4 mimic-ECL1[97-110]-6-Ahx-12-Ado-ECL2[182-196])

生物&药学活性

物理化学性质&存储条件

参考文献

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