miR-21 inhibitor 37

Chemical Structure : miR-21 inhibitor 37

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货号: PC-35404Not For Human Use, Lab Use Only.

miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122.

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1 g		Get quote

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生物&药学活性

miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels in A498 RCC cells, sensitizes cells to topotecan-induced apoptosis.

物理化学性质&存储条件

分子量	415.413
分子式	C21H17N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(3-(5-amino-4-(3-(4-(prop-2-yn-1-yloxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one oxime

参考文献

1. Naro Y, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.7b01891.