mPGES1-IN-3 | CAS 1469976-70-2 | Probechem Biochemicals

Chemical Structure : mPGES1-IN-3

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mPGES1-IN-3 (Compound 17d)

货号: PC-62797Not For Human Use, Lab Use Only.

mPGES1-IN-3 is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM.

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生物&药学活性

mPGES1-IN-3 is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM.
mPGES1-IN-3 displays excellent in vitro selectivity over mPGES-2, cPGES, COX1/2, other prostanoid synthases, favorable hERG and CEREP panel profile.
mPGES1-IN-3 shows good efficacy in LPS-induced thermal hyperalgesia pain model.
mPGES1-IN-3 demonstrates good oral pharmacokinetic profiles and good CNS B/P ratio in rat and guinea pig.

物理化学性质&存储条件

分子量	538.859
分子式	C24H16ClF5N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide

参考文献

1. Muthukaman N, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984.

mPGES1-IN-3 (Compound 17d)

生物&药学活性

物理化学性质&存储条件

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mPGES1-IN-3 (Compound 17d)

生物&药学活性

物理化学性质&存储条件

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