mCMY020 | TEAD inhibitor | Probechem Biochemicals

Chemical Structure : mCMY020

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mCMY020 (mCMY 020)

货号: PC-21290Not For Human Use, Lab Use Only.

mCMY020 is a potent, specific and covalent inhibitor of TEAD transcriptional activity with IC50 of 91.9-468.6 nM for TEAD1-4.

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生物&药学活性

mCMY020 is a potent, specific and covalent inhibitor of TEAD transcriptional activity with IC50 of 91.9-468.6 nM for TEAD1-4.
mCMY020 occupies the palmitoylation sites and form covalent adducts with recombinant preparations of TEAD1, TEAD2, TEAD3 and TEAD4.
mCMY020 does not significantly inhibit the catalytic activity of EGFR, BTK, and SARS-CoV-2 main protease (MPro).
mCMY020 inhibits TEAD-dependent transcriptional program (IC50=162.1 nM, MCF-7 cell line) and cell proliferation, markedly decreases the levels of the YAP-controlled transcripts CYR61, CTGF, and ANKRD1.
mCMY020 inhibits proliferation in Hippo pathway deficient cancers, potently inhibits NCI-H226 (NF2-deficient) and NCI-H2052 (homozygous for NF2 inactivating mutations) malignant mesotheliomas with IC50 of 261.3 nM and 228.7 nM, respectively.

物理化学性质&存储条件

分子量	364.42
分子式	C21H21FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-cyclohexylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluoroacrylamide

参考文献

1. Kayla Nutsch, et al. RSC Chem Biol. 2023 Aug 29;4(11):894-905.

mCMY020 (mCMY 020)

生物&药学活性

物理化学性质&存储条件

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mCMY020 (mCMY 020)

生物&药学活性

物理化学性质&存储条件

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