mCLC846 | MST1/2 inhibitor | Probechem Biochemicals

Chemical Structure : mCLC846

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mCLC846 (mCLC 846)

货号: PC-21957Not For Human Use, Lab Use Only.

mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively.

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生物&药学活性

mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively.
mCLC846 protects islet cells in diabetogenic conditions in vitro.
mCLC846 is cytoprotective through on target MST1 inhibition and reduction of caspase 3 activation in cytotoxic environments.
mCLC846 accelerates murine liver regeneration following partial hepatectomy.
mCLC846 activates YAP, TAZ, and is required for accelerated murine liver regeneration.
Oral delivery of mCLC846 perioperatively resulted in accelerated murine liver regeneration and improved survival in diet induced MASH models. Bulk transcriptional analysis of regenerating liver remnants suggested that mCLC846 enhanced the normal regenerative pathways induced following liver resection.

物理化学性质&存储条件

分子量	570.42
分子式	C28H23Cl2F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-chloro-4-((6-chloropyridin-2-yl)methoxy)-5-fluorophenyl)amino)-6-fluoro-7-(piperidin-4-ylmethoxy)quinoline-3-carbonitrile

参考文献

1. Ryan Watkins, et al. PNAS Nexus, 01 March 2024.

mCLC846 (mCLC 846)

生物&药学活性

物理化学性质&存储条件

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mCLC846 (mCLC 846)

生物&药学活性

物理化学性质&存储条件

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