mCLB073 | Rv1625c agonist | Probechem Biochemicals

Chemical Structure : mCLB073

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mCLB073 (mCLB 073)

货号: PC-72874Not For Human Use, Lab Use Only.

mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.

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生物&药学活性

mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.
mCLB073 exhibited 17-fold potency improvement against Mtb in cholesterol media relative to V-59 while maintaining excellent pharmacokinetic properties and a good safety profile.
mCLB073 (30 mg/kg, oral) reduced Mtb CFUs in the lungs of mice significantly and decreased the extent of lung pathology by 45%.

物理化学性质&存储条件

分子量	421.282
分子式	C18H18Cl2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-(3,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)-1-piperidinyl)-2-(2-methyl-2H-1,2,4-triazol-3-yl)-1-ethanone

参考文献

1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862.

mCLB073 (mCLB 073)

生物&药学活性

物理化学性质&存储条件

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mCLB073 (mCLB 073)

生物&药学活性

物理化学性质&存储条件

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