kt-3283 | PARP-HDAC inhibitor | Probechem Biochemicals

Chemical Structure : kt-3283

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kt-3283 (kt3283)

货号: PC-21009Not For Human Use, Lab Use Only.

kt-3283 is a novel bi-functional PARP-HDAC inhibitor with IC50 of 0.338 nM, 2.19 nM and 1.89 uM for PARP1, PARP2 and HDACs, respectively.

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生物&药学活性

kt-3283 is a novel bi-functional PARP-HDAC inhibitor with IC50 of 0.338 nM, 2.19 nM and 1.89 uM for PARP1, PARP2 and HDACs, respectively.
kt-3283 displayed enhanced cytotoxicity in Ewing sarcoma models, compared to FDA-approved PARP (olaparib) and HDAC (vorinostat) inhibitors.
The kt-3283-induced cytotoxicity was associated with strong S and G2/M cell cycle arrest in nanomolar concentration range and elevated DNA damage as assessed by γH2AX tracking and comet assays.
kt-3283 showed efficacy in lower concentrations than olaparib and vorinostat and kt-3283 inhibited colonization of Ewing sarcoma cells in the ex vivo PuMA model.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Louise Ramos, et al. Clin Cancer Res. 2023 Jun 6;CCR-22-3897.

kt-3283 (kt3283)

生物&药学活性

物理化学性质&存储条件

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kt-3283 (kt3283)

生物&药学活性

物理化学性质&存储条件

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