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首页-小分子抑制剂&激动剂-Apoptosis-Ferroptosis-icFSP1
icFSP1

Chemical Structure : icFSP1

CAS No.: 1115910-36-5

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icFSP1 (FSP1 inhibitor)

货号: PC-20966Not For Human Use, Lab Use Only.

icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation.

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1 mg ￥1980 In stock
5 mg ￥4280 In stock
10 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation.
Unlike iFSP1 (Cat. PC-38437), the first described on-target FSP1 inhibitor, icFSP1 does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition.
icFSP1 icFSP1 induces ferroptosis in synergy with GPX4 inhibition, reduces cell viability only in cells overexpressing hFSP1.
icFSP1 specifically inhibits the human isoform, but not mouse FSP1 (mFSP1).
icFSP1 indirectly inhibits FSP1 by inducing condensate formation.
icFSP1 (50 mg /kg, i.p. twice a day) significantly inhibited tumour growth and decreased tumour weight, induced FSP1 condensates in xenograft tumour model, without affecting body weight.

物理化学性质&存储条件

分子量 459.50
分子式 C26H25N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(2-Methyl-4-oxoquinazolin-3(4H)-yl)phenyl)-2-(3,4,5-trimethoxyphenyl)acetamide

参考文献

1. Toshitaka Nakamura, et al. Nature. 2023 Jun 28. doi: 10.1038/s41586-023-06255-6.

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