iPRMT1

Chemical Structure : iPRMT1

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货号: PC-21345Not For Human Use, Lab Use Only.

iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs.

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生物&药学活性

iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs.
iPRMT1 inhibitscell growth with an EC50 of 90, 70, and 9 nM in MCF7, T47D, and MDA-MB-231 cells, respectively, while it has minimal cellular toxicity toward normal breast epithelial cells, MCF10A.
iPRMT1 inhibits PRMT1-mediated SRSF1 methylation, alternative splicing events, and breast cancer cell growth and tumorigenesis.
Combination treatment with iPRMT1 and SRSF1 phosphorylation inhibitor exhibits additive effects on suppressing breast cancer cell growth and tumorigenesis.

物理化学性质&存储条件

分子量	428.50
分子式	C24H24N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-6a,7-dihydroindolo[2,1-h]pteridin-6(5H)-one

参考文献

1. Wen-Juan Li, et al. Cell Rep. 2023 Nov 7;42(11):113385.

iPRMT1

生物&药学活性

物理化学性质&存储条件

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iPRMT1

生物&药学活性

物理化学性质&存储条件

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