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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-iPAF1C
iPAF1C

Chemical Structure : iPAF1C

CAS No.: 950403-60-8

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iPAF1C (PAF1C inhibitor)

货号: PC-20164Not For Human Use, Lab Use Only.

iPAF1C (PAF1C inhibitor) is a first-in-class, specific inhibitor of polymerase-associated factor 1 complex (PAF1C), iPAF1C binds specifically to CTR9 and disrupts of PAF1-CTR9 interaction, enhances HIV-1 latency reversal.

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10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

iPAF1C (PAF1C inhibitor) is a first-in-class, specific inhibitor of polymerase-associated factor 1 complex (PAF1C), iPAF1C binds specifically to CTR9 and disrupts of PAF1-CTR9 interaction, enhances HIV-1 latency reversal.
iPAF1C impairs the genome-wide chromatin occupancy of PAF1 and induces global release of RNA Pol II from the promoter-proximal region into gene bodies.
iPAF1C reduces RNA Pol II pausing at HS–down-regulated genes.
iPAF1C treatment closely phenocopies the transcriptional impacts of acute PAF1 depletion.
iPAF1C enhances the activity of latency-reversing agents (LRAs) by enhancing transcriptional elongation of integrated HIV-1 proviruses.
iPAF1C reverses HIV-1 latency in peripheral blood mononuclear cells (PBMCs) from persons living with HIV-1 (PLWH).

物理化学性质&存储条件

分子量 521.43
分子式 C27H26BrFN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-bromo-3-methylphenyl)-1-(1-(3-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide

参考文献

1. Soliman SHA, et al. Sci Adv. 2023 Mar 10;9(10):eadf2468.

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