iP300w | p300/CBP inhibitor | Probechem Biochemicals

Chemical Structure : iP300w

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iP300w (CP-C27, CBP and p300 inhibitor compound 27)

货号: PC-73089Not For Human Use, Lab Use Only.

iP300w (CP-C27) is a potent, selective, orally bioavailable inhibitor of p300/CBP histone acetyltransferases with IC50 of 19 nM (p300), H3K27Ac EC50 of 5 nM, does not inhibitor other HATs.

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生物&药学活性

iP300w (CP-C27) is a potent, selective, orally bioavailable inhibitor of p300/CBP histone acetyltransferases with IC50 of 19 nM (p300), H3K27Ac EC50 of 5 nM, does not inhibitor other HATs.
iP300w is a potent p300/CBP inhibitor, inhibits p300-mediated H3K9 acetylation with IC50 of 33 nM in HTRF assay.
iP300w diminishes DUX4-induced toxicity and inhibits DUX4-mediated transcription.
iP300w blocks DUX4-induced H3 acetylation and prevents the increase in expression of DUX4 target genes, erases the DUX4-mediated transcriptional fingerprint in FSHD myoblasts.
iP300w impairs DUX4-mediated transcription in vivo in the iDUX4pA FSHD mouse model.

物理化学性质&存储条件

分子量	618.565
分子式	C29H27F5N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1'S,3'R)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide

参考文献

1. Bosnakovski D, et al. Sci Adv. 2019 Sep 11;5(9):eaaw7781.

2. Bosnakovski D, et al. Oncogenesis. 2021 Oct 12;10(10):68.

iP300w (CP-C27, CBP and p300 inhibitor compound 27)

生物&药学活性

物理化学性质&存储条件

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iP300w (CP-C27, CBP and p300 inhibitor compound 27)

生物&药学活性

物理化学性质&存储条件

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