iNUB |CAS:352336-00-6 Probechem Biochemicals

Chemical Structure : iNUB

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iNUB (Inhibitor of NEMO-Ub binding)

货号: PC-60552Not For Human Use, Lab Use Only.

iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

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生物&药学活性

iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.
iNUB binds to NEMO UBAN (ubiquitin binding domain (UBAN)) and competes for interaction with methionine-1-linked linear ubiquitin chains.
iNUB inhibits UBAN-dependent NF-κB activation upon TNFα and TCR/CD28 stimulation, shows selective toxicity to IKK/NF-κB dependent ABC-DLBCL

物理化学性质&存储条件

分子量	384.387
分子式	C24H16O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl 2-phenylcyclopropane-1-carboxylate

参考文献

1. Vincendeau M, et al. Sci Rep. 2016 Jan 7;6:18934.

iNUB (Inhibitor of NEMO-Ub binding)

生物&药学活性

物理化学性质&存储条件

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iNUB (Inhibitor of NEMO-Ub binding)

生物&药学活性

物理化学性质&存储条件

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