iJak-381 |CAS:1831144-46-7 Probechem Biochemicals

Chemical Structure : iJak-381

CAS No.: 1831144-46-7

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iJak-381 (iJak381)

货号: PC-35830Not For Human Use, Lab Use Only.

iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2.

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5 mg	￥2580	In stock
10 mg	￥4180	In stock
25 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2.
iJak-381 suppresses STAT 6 activation by IL-1, suppresses ovalbumin-induced lung inflammation in both murine and guinea pig asthma models and improved allergen-induced airway hyperresponsiveness in mice.
In a model driven by human allergens, iJak-381 had a more potent suppressive effect on neutrophil-driven inflammation compared to systemic corticosteroid administration, reduces lung pathology without affecting systemic Jak1 activity in rodents.

物理化学性质&存储条件

分子量	612.039
分子式	C28H28ClF2N9O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyanoethyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

参考文献

1. Dengler HS, et al. Sci Transl Med. 2018 Nov 21;10(468). pii: eaao2151. doi: 10.1126/scitranslmed.aao2151.

iJak-381 (iJak381)

生物&药学活性

物理化学性质&存储条件

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iJak-381 (iJak381)

生物&药学活性

物理化学性质&存储条件

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