iFSP1 | FSP1 inhibitor | Probechem Biochemicals

Chemical Structure : iFSP1

CAS No.: 150651-39-1

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iFSP1 (FSP1 inhibitor)

货号: PC-38437Not For Human Use, Lab Use Only.

iFSP1 (FSP1 inhibitor) is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, AIFM2) with IC50 of 103 nM.

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25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
250 mg		Get quote

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生物&药学活性

iFSP1 (FSP1 inhibitor) is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, AIFM2) with IC50 of 103 nM.
iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1.
iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer.
iFSP1 inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth.
iFSP1 sensitizes KEAP1 deficient lung cancer cells to radiation by inducing ferroptosis.

物理化学性质&存储条件

分子量	323.35
分子式	C20H13N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile

参考文献

1. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019 Nov;575(7784):693-698.

iFSP1 (FSP1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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iFSP1 (FSP1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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