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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-iCRT3
iCRT3

Chemical Structure : iCRT3

CAS No.: 901751-47-1

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iCRT3 (iCRT-3)

货号: PC-62166Not For Human Use, Lab Use Only.

iCRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM.

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

iCRT3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM.
iCRT3 interferes with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25-75 uM).
iCRT3 selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25-100 µg/ml).

物理化学性质&存储条件

分子量 394.53
分子式 C23H26N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide

参考文献

1. Lee E, et al. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15710-5.

2. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63.

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