iCDK9 |CAS:1263369-28-3 Probechem Biochemicals

Chemical Structure : iCDK9

CAS No.: 1263369-28-3

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iCDK9 (i-CDK9, CDK9-IN-2)

货号: PC-35631Not For Human Use, Lab Use Only.

iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

iCDK9 (i-CDK9, CDK9-IN-2) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
iCDK9 potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing.
iCDK9 efficiently suppresses P-TEFb's phosphorylation of the Pol II CTD and the DSIF subunit SPT5 and causes widespread Pol II pausing at gene promoters, enhances the MYC mRNA production but not protein stability.

物理化学性质&存储条件

分子量	425.936
分子式	C23H25ClFN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2'-((1r,4r)-4-aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine

参考文献

1. Lu H, et al. Elife. 2015 Jun 17;4:e06535. doi: 10.7554/eLife.06535.

iCDK9 (i-CDK9, CDK9-IN-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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iCDK9 (i-CDK9, CDK9-IN-2)

生物&药学活性

物理化学性质&存储条件

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