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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-iBFAR2
iBFAR2

Chemical Structure : iBFAR2

CAS No.: 353484-02-3

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iBFAR2 (BFAR inhibitor)

货号: PC-23528Not For Human Use, Lab Use Only.

iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice.
iBFAR2 rescued the antitumor activity of aged CD8+ T cells by restoring tissue resident memory T (TRM) generation in the tumor microenvironment.
iBFAR2 efficiently inhibited tumor growth in aged CD8+ T cell transfer and anti-programmed cell death protein 1 (PD-1)-resistant mouse tumor models.
The E3 ligase BFAR suppressed cytokine-induced JAK2 signaling by activating JAK2 deubiquitination through the deubiquitinase USP39, thereby limiting downstream STAT1-mediated TRM reprogramming.

物理化学性质&存储条件

分子量 360.34
分子式 C19H15F3N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-nitrophenyl)-6-(trifluoromethyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

参考文献

1. Pei S, et al. Nat Aging. 2024 Nov 26. doi: 10.1038/s43587-024-00746-5.

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