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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glutaminase-hTG2 inhibitor VA4
hTG2 inhibitor VA4

Chemical Structure : hTG2 inhibitor VA4

CAS No.: 2088001-23-2

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hTG2 inhibitor VA4 (VA4)

货号: PC-61052Not For Human Use, Lab Use Only.

hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    hTG2 inhibitor VA4 (VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency.
    hTG2 inhibitor VA4 inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context.
    hTG2 inhibitor VA4 inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.

    物理化学性质&存储条件

    分子量 635.78
    分子式 C33H41N5O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-Benzyl (6-Acrylamido-1-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate

    参考文献

    1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927.

    2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11.

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