hSMG-1 inhibitor 11j |CAS:1402452-15-6 Probechem Biochemicals

Chemical Structure : hSMG-1 inhibitor 11j

CAS No.: 1402452-15-6

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hSMG-1 inhibitor 11j (SMG1i)

货号: PC-35721Not For Human Use, Lab Use Only.

hSMG-1 inhibitor 11j (SMG1i) is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2.

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2 mg	￥1880	In stock
5 mg	￥2980	In stock
10 mg	￥4880	In stock
25 mg		Get quote

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生物&药学活性

hSMG-1 inhibitor 11j (SMG1i) is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2.
SMG1i eliminates UPF1 phosphorylation at 1 uM and significantly reduced it at 0.3 uM, shows little apparent effect on phospho p70s6 K and phospho AKT, targets of mTOR and PI3K.
SMG1i specifically inhibits SMG1 in vitro by competing with ATP binding.
SMG1i also shows good inhibition in an MDA468 cell proliferation assay with an IC50 of 75 nM, providing a tool compound to probe hSMG-1 mediated tumor biology.

物理化学性质&存储条件

分子量	566.077
分子式	C27H28ClN7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N,N-diethyl-5-((4-(2-(4-(3-methylureido)phenyl)pyridin-4-yl)pyrimidin-2-yl)amino)benzenesulfonamide

参考文献

1. Gopalsamy A, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.
2. Lukas M Langer, et al. Elife. 2021 Oct 26;10:e72353.

hSMG-1 inhibitor 11j (SMG1i)

生物&药学活性

物理化学性质&存储条件

参考文献

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hSMG-1 inhibitor 11j (SMG1i)

生物&药学活性

物理化学性质&存储条件

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