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首页-小分子抑制剂&激动剂-Others-Other Targets-hPIF1 inhibitor 6
hPIF1 inhibitor 6

Chemical Structure : hPIF1 inhibitor 6

CAS No.: 1198088-48-0

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hPIF1 inhibitor 6

货号: PC-23216Not For Human Use, Lab Use Only.

hPIF1 inhibitor 6 is a specific small molecule inhibitor targeting the helicase activity of human PIF1 with IC50 of 36 uM for inhibition of FLhPIF1 helicase activity, 22-fold selective over hUPF1, inhibits hPIF1 DNA-binding and helicase activity in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

hPIF1 inhibitor 6 is a specific small molecule inhibitor targeting the helicase activity of human PIF1 with IC50 of 36 uM for inhibition of FLhPIF1 helicase activity, 22-fold selective over hUPF1, inhibits hPIF1 DNA-binding and helicase activity in vitro.
PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability.

物理化学性质&存储条件

分子量 280.35
分子式 C16H12N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(2-aminothiazol-4-yl)phenyl)(phenyl)methanone

参考文献

1. Wever MJA, et al. Nucleic Acids Res. 2024 Oct 17:gkae897.

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