hNPR1 inhibitor JS-11 (JS11)

Chemical Structure : hNPR1 inhibitor JS-11

CAS No.: 1394592-04-1

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货号: PC-72071Not For Human Use, Lab Use Only.

hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.
hNPR1 inhibitor JS-11 inhibits hNPR1 receptor activity through a non-competitive mechanism.
hNPR1 inhibitor JS-11 reduced scratching responses to histamine-challenged mice and attenuated CYM5442-induced scratching in vivo, reduced the number of c-FOS-positive neurons to intradermal histamine challenge.
hNPR1 inhibitor JS-11 inhibited itching in a mouse model of contact dermatitis

物理化学性质&存储条件

分子量	408.502
分子式	C23H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide

参考文献

1. Hans Jürgen Solinski, et al. Sci Transl Med. 2019 Jul 10;11(500):eaav5464.