eIF4E-RBM38 inhibitor 094 | eIF4E-RBM38 inhibitor | Probechem Biochemicals

Chemical Structure : eIF4E-RBM38 inhibitor 094

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eIF4E-RBM38 inhibitor 094 (Compound 094)

货号: PC-20483Not For Human Use, Lab Use Only.

eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners.

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生物&药学活性

eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners.
Compound 094 enhances p53 de-novo protein expression in wild-type, but not in eIF4E ∆-Cterm HCT116 cells, enhances p53 expression through enhancing its mRNA translation.
Compound 094 inhibits tumor cell growth and enhances doxorubicin-mediated growth suppression.

物理化学性质&存储条件

分子量	339.37
分子式	C19H18FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethyl-N-(4-(2-fluorophenyl)-6-oxo-1,4,5,6-tetrahydropyrimidin-2-yl)benzamide

参考文献

1. Lucchesi CA, et al. Mol Cancer Ther. 2023 Mar 20:MCT-22-0627.

eIF4E-RBM38 inhibitor 094 (Compound 094)

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eIF4E-RBM38 inhibitor 094 (Compound 094)

生物&药学活性

物理化学性质&存储条件

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