eIF4A inhibitor 28

Chemical Structure : eIF4A inhibitor 28

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货号: PC-49308Not For Human Use, Lab Use Only.

eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively.

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生物&药学活性

eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively.
eIF4A inhibitor 28 decreases BJAB Burkitt lymphoma cell viability with IC50 of 0.46 uM.
eIF4A inhibitor 28 engages a novel pocket in the RNA groove of eIF4A and inhibits unwinding activity by interfering with proper RNA binding and suppressing ATP hydrolysis.

物理化学性质&存储条件

分子量	416.433
分子式	C24H20N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(4-butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid

参考文献

1. Zerio CJ, et al. J Med Chem. 2021 Nov 11;64(21):15727-15746.