eIF4A3 inhibitor 53a | eIF4A3 inhibitor Probechem Biochemicals

Chemical Structure : eIF4A3 inhibitor 53a

CAS No.: 2095486-67-0

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eIF4A3 inhibitor 53a (eIF4A3-IN-1)

货号: PC-61019Not For Human Use, Lab Use Only.

eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM.

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2 mg	￥2480	In stock
5 mg	￥3780	In stock
10 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

eIF4A3 inhibitor 53a (eIF4A3-IN-1) is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM.
eIF4A3 inhibitor 53a displays no activity against eIF4A1, eIF4A2, DHX29 and BRR2 ATPase (IC50>100 uM).
eIF4A3 inhibitor 53a binds to a non-ATP binding site of eIF4A3, exhibits cellular nonsense-mediated RNA decay (NMD) inhibitory activity and represents a novel molecular probe for further study of eIF4A3, the exon junction complex (EJC) and NMD.

物理化学性质&存储条件

分子量	588.89
分子式	C29H23BrClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(((3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)-piperazin-1-yl)carbonyl)-5-methyl-1H-pyrazol-1-yl)-benzonitrile

参考文献

1. Ito M, et al. J Med Chem. 2017 Apr 27;60(8):3335-3351.

eIF4A3 inhibitor 53a (eIF4A3-IN-1)

生物&药学活性

物理化学性质&存储条件

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eIF4A3 inhibitor 53a (eIF4A3-IN-1)

生物&药学活性

物理化学性质&存储条件

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