eIF4A3-IN-2

Chemical Structure : eIF4A3-IN-2

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货号: PC-62424Not For Human Use, Lab Use Only.

eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.

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生物&药学活性

eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.
eIF4A3-IN-2 suppresses the helicase activity of eIF4A3 in an ATPase-dependent manner.
eIF4A3-IN-2 targets the exon junction complex (EJC) and suppresses monsense-mediated mRNA decay.

物理化学性质&存储条件

分子量	602.711
分子式	C25H19Br2ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone

参考文献

1. Iwatani-Yoshihara M, et al. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.

eIF4A3-IN-2

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物理化学性质&存储条件

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eIF4A3-IN-2

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