eIF4A3-IN-1q

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-eIF4A3-IN-1q

Chemical Structure : eIF4A3-IN-1q

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货号: PC-60161Not For Human Use, Lab Use Only.

eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.
eIF4A3-IN-1q displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM).
eIF4A3-IN-1q upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM).
eIF4A3-IN-1q shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss.

物理化学性质&存储条件

分子量	645.861
分子式	C29H21BrClF3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(4-(5-bromopicolinoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl)-1-phenyl-3-(trifluoromethyl)pyridin-2(1H)-one

参考文献

1. Mizojiri R, et al. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082.

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eIF4A3-IN-1q

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