Tomivosertib (eFT508) | MNK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : eFT508

CAS No.: 1849590-01-7

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eFT508 (eFT 508, Tomivosertib)

货号: PC-42035Not For Human Use, Lab Use Only.

eFT508 (Tomivosertib) is a potent, highly selective, reversible, ATP-competitive, and orally bioavailable MNK1 and MNK2 inhibitor with IC50 of 1-2 nM in enzyme assays.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

eFT508 (Tomivosertib) is a potent, highly selective, reversible, ATP-competitive, and orally bioavailable MNK1 and MNK2 inhibitor with IC50 of 1-2 nM in enzyme assays.
eFT508 (Tomivosertib) dose-dependently reduces eIF4E phosphorylation at Serine 209 in tumor cell lines with IC50 of 2-16 nM.
eFT508 (Tomivosertib) shows anti-proliferative activity against multiple DLBCL cell lines, decreases the production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10.
eFT508 (Tomivosertib) demonstrates significant anti-tumor activity in human lymphoma xenograft models which harbor activating MyD88 mutations.

物理化学性质&存储条件

分子量	340.3797
分子式	C17H20N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6 mg/mL (Need ultrasonic)
Chemical Name/SMILES	Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-

参考文献

1. Kevin R. Webster, et al. Blood 2015 126:1554;

2. Dreas A, et al. Curr Med Chem. 2017;24(28):3025-3053.

eFT508 (eFT 508, Tomivosertib)

生物&药学活性

物理化学性质&存储条件

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eFT508 (eFT 508, Tomivosertib)

生物&药学活性

物理化学性质&存储条件

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