eEF-2K inhibitor 2C | eEF-2K inhibitor | Probechem Biochemicals

Chemical Structure : eEF-2K inhibitor 2C

加入收藏

eEF-2K inhibitor 2C (Compound 2C)

货号: PC-20825Not For Human Use, Lab Use Only.

eEF-2K inhibitor 2C (Compound 2C) is a small molecule inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K), binds to the ATP-binding site of eEF-2K.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

eEF-2K inhibitor 2C (Compound 2C) is a small molecule inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K), binds to the ATP-binding site of eEF-2K.
eEF-2K inhibitor 2C (Compound 2C) (−7.691 kcal/mol) has better docking scores than some of the published eEF-2K inhibitors such as nonpotent inhibitor A484954 (−5.621 kcal/mol), NH125 (−4.503 kcal/mol), and TX-1918 (−5.533 kcal/mol), except for nonspecific eEF-2K inhibitor Rottlerin (−8.263 kcal/mol).
eEF-2K inhibitor 2C (Compound 2C) (<1 uM) inhibits proliferation and colony formation in breast cancer cells, including highly aggressive and invasive TNBC cells such as MDA-MB-231 (p53- and Kras-mutated), BT-20 (PI3K- and p53-mutated), and MDA-MB-436 (p53- and BRCA1-mutated) and noninvasive MCF-7 (ER+) cells.
eEF-2K inhibitor 2C (Compound 2C) inhibits activity of eEF-2K as indicated by reduced phosphorylation of its downstream target EF2, induces apoptosis in TNBC cells.
Treatment with single-lipid nanoparticle incorporating eEF-2K inhibitor 2C (Compound 2C) (20 mg/kg) significantly inhibited tumor growth, led to significant reduction in eEF-2K activity as indicated by reduced levels of p-EF2 (Thr56) in MDA-MB-231 tumor xenographs in highly aggressive TNBC tumor models.

物理化学性质&存储条件

分子量	344.29
分子式	C19H11F3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-(3-(trifluoromethyl)phenyl)acryloyl)-2H-chromen-2-one

参考文献

1. Ferah Comert Onder, et al. ACS Pharmacol Transl Sci. 2021 Mar 30;4(2):926-940.

eEF-2K inhibitor 2C (Compound 2C)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

eEF-2K inhibitor 2C (Compound 2C)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.