dEF3122 | NAF-1 inhibitor | Probechem Biochemicals

Chemical Structure : dEF3122

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dEF3122 (dEF 3122)

货号: PC-21723Not For Human Use, Lab Use Only.

dEF3122 is a highly potent small molecule inhibitor of influenza virus replication with IC50 of 3 nM in neuraminidase activity assays, taregts NEET family of protein NAF-1.

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生物&药学活性

dEF3122 is a highly potent small molecule inhibitor of influenza virus replication with IC50 of 3 nM in neuraminidase activity assays, taregts NEET family of protein NAF-1.
Oral administration of dEF3122 for 8 wk resolved portal inflammation and fibrosis in the liver in mouse model recapitulated phenotypes of NASH associated with chronic kidney disease.
dEF3122 counteracts virus- induced mitochondria network hyperfusion.

物理化学性质&存储条件

分子量	377.46
分子式	C22H19NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-benzamido-4-(1,2,3,4-tetrahydronaphthalen-2-yl)thiophene-3-carboxylic acid

参考文献

1. Meyniel-Schicklin L, et al. Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2308776121.

dEF3122 (dEF 3122)

生物&药学活性

物理化学性质&存储条件

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dEF3122 (dEF 3122)

生物&药学活性

物理化学性质&存储条件

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