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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-dCTPP1-IN-1
dCTPP1-IN-1

Chemical Structure : dCTPP1-IN-1

CAS No.: 2098200-95-2

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dCTPP1-IN-1

货号: PC-27240Not For Human Use, Lab Use Only.

dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells.

物理化学性质&存储条件

分子量 470.52
分子式 C22H23FN6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorobenzyl)-6-(4-((2-methylpyridin-3-yl)sulfonyl)piperazin-1-yl)pyridazine-3-carboxamide

参考文献

1. Hauk G, et al. roc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2534029123.

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