c-Myc inhibitor DJ34 | c-Myc inhibitor | Probechem Biochemicals

Chemical Structure : c-Myc inhibitor DJ34

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c-Myc inhibitor DJ34 (DJ34)

货号: PC-49522Not For Human Use, Lab Use Only.

DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.

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生物&药学活性

DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
DJ34 selectively kills BCR–Abl-positive leukemia cells, inhibits the c-Myc transcriptional program and activates the p53 program.
DJ34 induces depletion of c-Myc in a wide variety of tumor types, induces depletion of c-MYC mRNA.
DJ34 intercalates DNA and inhibits topoisomerase II but not topoisomerase I.
DJ34 induces cell cycle arrest, apoptosis, and differentiation.
DJ34 also shows anti- leukemic stem cells (LSCs) acitvities.

物理化学性质&存储条件

分子量	288.35
分子式	C18H16N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-imidazol-4-yl)ethyl)acridin-9-amine

参考文献

1. Tadele DS, et al. J Biol Chem. 2021 Jan-Jun;296:100179.

c-Myc inhibitor DJ34 (DJ34)

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物理化学性质&存储条件

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c-Myc inhibitor DJ34 (DJ34)

生物&药学活性

物理化学性质&存储条件

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