MSAB is a selective, direct inhibitor of Wnt/β-catenin signaling, binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
MSAB is a selective, direct inhibitor of Wnt/β-catenin signaling, binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB inhibited proliferation of Wnt-dependent cancer cell lines, but had little effect on the viability of normal or immortalized breast epithelial cells. MSAB inhibits β-catenin activity and induces proteasome-dependent degradation of β-catenin. MSAB suppress the increase of active β-catenin levels in HEK293T cells induced by Wnt3a-CM treatment MSAB inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model.
