anle145c

Chemical Structure : anle145c

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货号: PC-73121Not For Human Use, Lab Use Only.

anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.

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生物&药学活性

anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.
anle145c has a special mode of action in which anle145c-stabilized oligomers act as a thermodynamic sink for the preferred aggregation state of hIAPP and anle145c.
anle145c prevents hIAPP fibril formation in solution, and converts preformed hIAPP fibrils into non-toxic oligomers.
anle145c is a promising candidate to inhibit protein aggregation in case of T2DM.

物理化学性质&存储条件

分子量	426.064
分子式	C15H10Br2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-(3,5-dibromophenyl)-1H-pyrazol-3-yl)benzene-1,2,3-triol

参考文献

1. Saravanan MS, et al. Sci Rep. 2019 Dec 13;9(1):19023.

anle145c

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anle145c

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