alpha-NETA (α-NETA)

Chemical Structure : alpha-NETA

CAS No.: 115066-04-1

加入收藏

货号: PC-21470Not For Human Use, Lab Use Only.

alpha-NETA (α-NETA) is a small molecule antagonist of chemerin receptor chemokine-like receptor 1 (CMKLR1), inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 with IC50 of 4.9 uM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

alpha-NETA (α-NETA) is a small molecule antagonist of chemerin receptor chemokine-like receptor 1 (CMKLR1), inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 with IC50 of 4.9 uM.
α-NETA also is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with IC50 of 9 uM.
α-NETA significantly suppresses experimental autoimmune encephalomyelitis (EAE) disease onset in vivo.
α-NETA reduces the clonogenicity and viability of neuroblastoma cell lines indicating the chemerin/CMKLR1 axis as a promoting factor in neuroblastoma tumorigenesis.
α-NETA impairs tumor growth in neuroblastoma SK-N-AS cells xenografts.

物理化学性质&存储条件

分子量	369.25
分子式	C16H20INO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(alpha-Naphthoyl) ethyltrimethylammonium iodide

参考文献

1. Kumar V, et al. Sci Rep. 2019 May 9;9(1):7178.

2. Aleksandrov AA, et al. Neurosci Lett. 2019 Jun 21;704:208-211.

3. Graham KL, et al. PLoS One. 2014 Dec 1;9(12):e112925.

4. Sastry BV, et al. J Pharmacol Exp Ther. 1988 Apr;245(1):72-80.