aNDR1 | NDR1 agonist | Probechem Biochemicals

Chemical Structure : aNDR1

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aNDR1 (NDR1 agonist)

货号: PC-21860Not For Human Use, Lab Use Only.

aNDR1 (NDR1 agonist) is a specific small-molecule agonist of Nuclear Dbf2-related kinase 1 (NDR1, STK38), specifically inhibits CRPC cells and promotes kinase activity of NDR1.

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生物&药学活性

aNDR1 (NDR1 agonist) is a specific small-molecule agonist of Nuclear Dbf2-related kinase 1 (NDR1, STK38), specifically inhibits CRPC cells and promotes kinase activity of NDR1.
aNDR1 is tumor specific, significantly inhibits growth in PCa cells with IC50 of 1.178 uM and 1.763 uM for PC3 and DU145 cells respectivel, does not display noticeable cytotoxicity in WPMY-1 cells.
aNDR1 inhibits proliferation and migration and induces apoptosis of PCa cells in vitro.
aNDR1 increases the expression of NDR1 and can directly bind to NDR1.
aNDR1 (5 mg/kg) inhibits the growth and metastasis of PCa cells in prostate cancer cell xenograft model, with no obvious toxic pathologic damage in the heart, liver, spleen, lungs, or kidneys.
NDR1, also known as STK38, belongs to the NDR (nuclear Dbf2 related) kinase family, regulating cell mitosis, embryonic development, centrosome replication and organ size.
NDR1 mainly functions as a member of the Hippo pathway by cooperating with NDR2, LATS1 and LATS2 to phosphorylate YAP and regulate its activity.

物理化学性质&存储条件

分子量	460.87
分子式	C19H14ClFN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(6-chloro-5-((4-fluorophenyl)sulfonamido)pyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

参考文献

1. Bai Y, et al. Front Pharmacol. 2024 Feb 12;15:1367358.