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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Zotiraciclib
Zotiraciclib

Chemical Structure : Zotiraciclib

CAS No.: 937270-47-8

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Zotiraciclib (TG02, (E/Z)-TG02, (E/Z)-SB1317)

货号: PC-38758Not For Human Use, Lab Use Only.

Zotiraciclib (TG02, SB1317) is a potent multi-kinase inhibitor of cyclin dependent kinases (CDKs), JAK2, and FLT3 with IC50of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.

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5 mg ￥780 In stock
10 mg ￥1280 In stock
50 mg ￥2880 In stock
100 mg ￥4980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zotiraciclib (TG02, SB1317) is a potent multi-kinase inhibitor of cyclin dependent kinases (CDKs), JAK2, and FLT3 with IC50of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
Zotiraciclib (TG02, SB1317) is anti-proliferative in a broad range of tumor cell lines, inducing G1 cell cycle arrest and apoptosis.
Zotiraciclib (TG02, SB1317) shows high sensitivity to primary cultures of progenitor cells derived from acute myeloid leukemia (AML) and polycythemia vera patients.
Zotiraciclib (TG02, SB1317) exhibits favorable pharmacokinetics after oral dosing in xenograft models and accumulates in tumor tissues, inducing an effective blockade of both CDK and STAT signaling.
Zotiraciclib (TG02, SB1317) also shows oral efficacy in colon (HCT-116) and lymphoma (Ramos) xenografts.

物理化学性质&存储条件

分子量 372.46
分子式 C23H24N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

20-Oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-methyl-

参考文献

1. Ortiz-Ruiz MJ, et al. Oncotarget. 2014 Nov 30;5(22):11308-18.

2. Poulsen A, et al. J Mol Model. 2013 Jan;19(1):119-30.

3. William AD, et al. J Med Chem. 2012 Jan 12;55(1):169-96.

4. Goh KC, et al. Leukemia. 2012 Feb;26(2):236-43.

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