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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-Zotarolimus
Zotarolimus

Chemical Structure : Zotarolimus

CAS No.: 221877-54-9

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Zotarolimus (ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578)

货号: PC-43029Not For Human Use, Lab Use Only.

Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin.
Zotarolimus (ABT-578, A 179578) effectively inhibits both smooth muscle cell and endothelial cell proliferation, with IC50 values of 2.9 nM and 2.6 nM, respectively.
Zotarolimus (ABT-578, A 179578) exhibits high-affinity binding to the immunophilin FKBP12, inhibiting in vitro proliferation of both human and rat T cells.
Zotarolimus (ABT-578, A 179578) inhibits Con A-induced human T cells with IC50 of 7.0 nM.
Zotarolimus (ABT-578, A 179578) reduces early complications and improve late clinical outcomes in patients needing interventional cardiology.

物理化学性质&存储条件

分子量 966.21
分子式 C52H79N5O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-

参考文献

1. Garcia-Touchard A, et al. Eur Heart J. 2006 Apr;27(8):988-93.

2. Chen YW, et al. J Cardiovasc Pharmacol. 2007 Apr;49(4):228-35.

3. Abizaid A, et al. Am J Cardiol. 2007 May 15;99(10):1403-8.

4. Wagner R, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5340-3.

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