Zopolrestat | Aldose reductase inhibitor | Probechem Biochemicals

Chemical Structure : Zopolrestat

CAS No.: 110703-94-1

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Zopolrestat (CP73850, CP-73850)

货号: PC-25938Not For Human Use, Lab Use Only.

Zopolrestat (CP73850) is Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with IC50 of 3.1 nM (human placenta AR).

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
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生物&药学活性

Zopolrestat (CP73850) is Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with IC50 of 3.1 nM (human placenta AR).
Zopolrestat has ED50s of 1.9, 17.6, and 18.4 mg/kg in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test.

物理化学性质&存储条件

分子量	419.38
分子式	C19H12F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrophthalazin-1-yl)acetic acid

参考文献

1. Mylari BL, et al. J Med Chem. 1991 Jan;34(1):108-22.

2. Inskeep PB, et al. Pharm Res. 1991 Dec;8(12):1511-5.

Zopolrestat (CP73850, CP-73850)

生物&药学活性

物理化学性质&存储条件

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Zopolrestat (CP73850, CP-73850)

生物&药学活性

物理化学性质&存储条件

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