Zongertinib (BI 1810631) | HER2 inhibitor | Probechem Biochemicals

Chemical Structure : Zongertinib

CAS No.: 2728667-27-2

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Zongertinib (BI 1810631, BI-1810631)

货号: PC-20669Not For Human Use, Lab Use Only.

Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR.

Zongertinib (BI 1810631) is a potent and selective inhibitor of HER2-driven oncogenic signaling, efficiently blocks HER2 mutant-driven lung cancer.

reduces cell growth and survival in mutant HER2 driven Ba/F3 cell systems, in human tumor cell lines in vitro and translated into tumor regressions in a genome-engineered HER2-YVMA mutant xenograft model.

物理化学性质&存储条件

分子量	535.61
分子式	C29H29N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide

参考文献

1. Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800.
2. John Heymach, et al. Clin Lung Cancer. 2023 Mar;24(2):e65-e68.

Zongertinib (BI 1810631, BI-1810631)

生物&药学活性

物理化学性质&存储条件

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Zongertinib (BI 1810631, BI-1810631)

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