Zonampanel |CAS:210245-80-0 Probechem Biochemicals

Chemical Structure : Zonampanel

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Zonampanel (YM872, YM-872)

货号: PC-61711Not For Human Use, Lab Use Only.

Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.

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生物&药学活性

Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.
Zonampanel (YM 872) shows very low affinity for other ionotropic glutamate receptors.
Zonampanel (YM 872) competitively antagonizes kainate-induced currents in Xenopus laevis oocytes with a pA2 value of 6.97.
Zonampanel (YM 872) exhibits great potential for treatment of neurodegenerative disorders such as stroke.

物理化学性质&存储条件

分子量	331.241
分子式	C13H9N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalineacetic acid

参考文献

1. Shimizu-Sasamata M, et al. Stroke. 1998 Oct;29(10):2141-8.

2. Takahashi M, et al. J Pharmacol Exp Ther. 1998 Feb;284(2):467-73.

3. Kohara A, et al. J Pharm Pharmacol. 1998 Jul;50(7):795-801.

Zonampanel (YM872, YM-872)

生物&药学活性

物理化学性质&存储条件

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Zonampanel (YM872, YM-872)

生物&药学活性

物理化学性质&存储条件

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