Zoligratinib |CAS:1265229-25-1 Probechem Biochemicals

Chemical Structure : Zoligratinib

CAS No.: 1265229-25-1

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Zoligratinib (Debio1347, CH5183284, Debio-1347, CH-5183284)

货号: PC-45761Not For Human Use, Lab Use Only.

CH-5183284 (Debio-1347, Debio1347) is a potent, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22 nM, respectively.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

CH5183284 (Zoligratinib, Debio1347) is a potent, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22 nM, respectively.
CH-5183284 displays >10-fold selectivity over FGFR4, and >100-fold over KDR, Src, and other kinases.
CH-5183284 displays preferential antitumor activity against cancer cells with various FGFR genetic alterations in a panel of 327 cancer cell lines and in xenograft models.
CH-5183284 can inhibit FGFR2 harboring one type of the gatekeeper mutation and blocks FGFR2 V564F-driven tumor growth.

物理化学性质&存储条件

分子量	356.3806
分子式	C20H16N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31mg/mL
Chemical Name/SMILES	Methanone, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-

参考文献

1. Ebiike H, et al. J Med Chem. 2016 Dec 8;59(23):10586-10600.

2. Nakanishi Y, et al. Mol Cancer Ther. 2014 Nov;13(11):2547-58.

3. Nakanishi Y, et al. Mol Cancer Ther. 2015 Dec;14(12):2831-9.

Zoligratinib (Debio1347, CH5183284, Debio-1347, CH-5183284)

生物&药学活性

物理化学性质&存储条件

参考文献

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Zoligratinib (Debio1347, CH5183284, Debio-1347, CH-5183284)

生物&药学活性

物理化学性质&存储条件

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