Zoliflodacin | DNA gyrase inhibitor | Probechem Biochemicals

Chemical Structure : Zoliflodacin

CAS No.: 1620458-09-4

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Zoliflodacin (AZD0914, ETX0914)

货号: PC-60475Not For Human Use, Lab Use Only.

Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.

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5 mg	￥2780	In stock
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生物&药学活性

Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
Zoliflodacin has the MIC90s for C. trachomatis and C. pneumoniaeare 0.25 ug/ml and 1 ug/ml, respectively, and the MBC90s are 0.5 ug/ml for C. trachomatis and 2 ug/ml for C. pneumoniae.

物理化学性质&存储条件

分子量	487.44
分子式	C22H22FN5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione

参考文献

1. Jacobsson S, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5585-8.

2. Kohlhoff SA, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7595-6.

3. Huband MD, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.

Zoliflodacin (AZD0914, ETX0914)

生物&药学活性

物理化学性质&存储条件

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Zoliflodacin (AZD0914, ETX0914)

生物&药学活性

物理化学性质&存储条件

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