Zimberelimab | Anti-PD-1 mAb | Probechem Biochemicals

Chemical Structure : Zimberelimab

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Zimberelimab (GLS-010, AB122)

货号: PC-38874Not For Human Use, Lab Use Only.

GLS-010 (Zimberelimab, AB122) is a fully human, monoclonal immunoglobulin G4 (IgG4) anti-programmed death-1 (PD-1) antibody that shows promising efficacy and safety in advanced solid tumors.

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生物&药学活性

GLS-010 (Zimberelimab, AB122) is a fully human, monoclonal immunoglobulin G4 (IgG4) anti-programmed death-1 (PD-1) antibody that shows promising efficacy and safety in advanced solid tumors.
GLS-010 (Zimberelimab) has a high affinity to PD-1 with dissociation constant (KD) of 0.175 nM.
GLS-010 (Zimberelimab) could effectively block the binding of PD-L1/2 to PD-1.
GLS-010 (Zimberelimab) showed statistically significant anti-tumor effects in the MC38 model in human PD-1 knock-in mice.

Isotype: IgG4-lambda.
Anti-[human PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Lin N, et al. Eur J Cancer. 2022 Mar;164:117-126.

2. Lou B, et al. Front Oncol. 2021 Sep 15;11:736955.

Zimberelimab (GLS-010, AB122)

生物&药学活性

物理化学性质&存储条件

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Zimberelimab (GLS-010, AB122)

生物&药学活性

物理化学性质&存储条件

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