Zilurgisertib (INCB000928, NBU-928)

Chemical Structure : Zilurgisertib

CAS No.: 2173389-57-4

加入收藏

货号: PC-73458Not For Human Use, Lab Use Only.

Zilurgisertib (INCB000928, NBU-928) is a potent, selective and orally available wild-type and mutant ALK2 (R206H) with IC50 of 19 nM.

规格	价格	库存
2 mg	￥2180	In stock
5 mg	￥3780	In stock
10 mg	￥5780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Zilurgisertib (INCB000928, NBU-928) is a potent, selective and orally available wild-type and mutant ALK2 (R206H) with IC50 of 19 nM.
Zilurgisertib (INCB000928, NBU-928) has high selectivity over other BMP and TGFβ signaling receptor kinases.
INCB000928 significantly reduces the production of hepcidin in human liver cells, primary hepatocytes and rodent models of anemia.
INCB000928 has shown efficacy in preventing injury-induced heterotopic ossification in a human FOP mouse model, offering a promising path to clinical proof-of-efficacy studies and potential benefits to patients with hepcidin-induced anemia and FOP

物理化学性质&存储条件

分子量	502.659
分子式	C30H38N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-N-(4-hydroxybicyclo[2.2.2]octan-1-yl)-5-(4-((1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl)phenyl)nicotinamide

参考文献

1. Li J, et al. Preparation of aminopyridine derivatives and their use as selective ALK-2 inhibitors. WO2018014829 A1.