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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-Zevaquenabant
Zevaquenabant

Chemical Structure : Zevaquenabant

CAS No.: 1998760-00-1

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Zevaquenabant ((S)-MRI-1867)

货号: PC-73457Not For Human Use, Lab Use Only.

Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual CB1 receptor/iNOS inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual CB1 receptor/iNOS inhibitor.
    Zevaquenabant ((S)-MRI-1867) (3 mg/kg, p.o.) ameliorated obesity-induced kidney morphological and functional changes via decreasing kidney inflammation, fibrosis, oxidative stress, and renal injury.
    The hybrid CB1R/iNOS inhibitor Zevaquenabant ((S)-MRI-1867) has greater antifibrotic efficacy than inhibition of CB1R alone.
    (S)-MRI-1867 reduced hepatic steatosis and the rate of hepatic VLDL secretion, upregulated hepatic LDLR expression, and reduced the circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diet-induced obesity (DIO mice).

    物理化学性质&存储条件

    分子量 547.981
    分子式 C25H21ClF3N5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S,Z)-N-((Z)-1-aminoethylidene)-3-(4-chlorophenyl)-4-phenyl-N'-((4-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydro-1H-pyrazole-1-carboximidamide

    参考文献

    1. Cinar R, et al. JCI Insight. 2017 Apr 20;2(8):e92281.

    2. Udi S, et al. Br J Pharmacol. 2020 Jan;177(1):110-127.

    3. Roger C, et al. Diabetes. 2020 Oct;69(10):2120-2132.

    4. Cinar R, et al. Clin Transl Med. 2021 Jul;11(7):e471.

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