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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-Zenuzolac
Zenuzolac

Chemical Structure : Zenuzolac

CAS No.: 6501-72-0 (racemate)

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Zenuzolac (GLS1027, VGX-1027)

货号: PC-38433Not For Human Use, Lab Use Only.

Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders.

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25 mg ￥1380 In stock
50 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders.
VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus.
VGX-1027 attenuates self-grooming and marble burying behaviors, and enhance social interactions in BTBR mice, VGX-1027 treatment resulted in a substantial decrease in IL-1β, IL-6, TNF-α, IFN-γ, and NF-κB p65 production, but increased IL-10 production in CD4+ T cells.

物理化学性质&存储条件

分子量 205.213
分子式 C11H11NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid

参考文献

1. Mangano K, et al. Br J Pharmacol. 2008 Nov;155(5):722-30.

2. Fagone P, et al. Immunology. 2014 Aug;142(4):594-602.

3. Laird MD, et al. Glia. 2014 Jan;62(1):26-38.

4. Sheikh F Ahmad, et al. Life Sci. 2019 Nov 15;237:116930.

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