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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-Zelquistinel
Zelquistinel

Chemical Structure : Zelquistinel

CAS No.: 2151842-64-5

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Zelquistinel (AGN-241751, GATE-251)

货号: PC-21853Not For Human Use, Lab Use Only.

Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons.
Zelquistinel (AGN-241751) (3-60 nM) potentiated NMDA-induced [Ca2+]i and inhibited responses at concentrations ≥100 nM, potentiates NMDA- or glutamate-induced changes in intracellular calcium.
Zelquistinel (AGN-241751), co-applied with NMDA, increases intracellular calcium in the presence of MDL 105,519.
Zelquistinel (AGN-241751) potentiates NMDAR-mediated excitatory postsynaptic currents and facilitates long-term potentiation in mPFC.
Zelquistinel (AGN-241751) dose-dependently produces and long-lasting antidepressant-like response， restores social approach behavior in stress-susceptible mice.

物理化学性质&存储条件

分子量 327.38
分子式 C15H25N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 2-[(1S,2R)-1-(aminocarbonyl)-2-hydroxypropyl]-1-oxo-, 1,1-dimethylethyl ester, (4S)-

参考文献

1. Burgdorf JS, et al. Int J Neuropsychopharmacol. 2022 Dec 12;25(12):979-991.

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