Zastaprazan (JP-1366) | Gastric H+/K+-ATPase inhibitor

Chemical Structure : Zastaprazan

CAS No.: 2133852-18-1

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Zastaprazan (JP-1366, JP1366)

货号: PC-38430Not For Human Use, Lab Use Only.

Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.

JP-1366 (2 mg/kg) inhibits basal and histamine-stimulated gastric acid secretion in pylorus-ligated rats.

JP-1366 inhibits esophageal mucosal damage in a reflux esophagitis model with ED50 of 0.53 mg/kg.

JP-1366 exhibits a more than 2-fold higher inhibitory effect on esophageal injury than TAK-438 in GERD lesions and has a more potent inhibitory effect in indomethacin- or aspirin-induced gastric ulcer rat models than TAK-438.

物理化学性质&存储条件

分子量	362.477
分子式	C22H26N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	azetidin-1-yl(8-((2,6-dimethylbenzyl)amino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)methanone

参考文献

1. Jin Mo Ku, et al. Pharmacol Res Perspect. 2023 Jun;11(3):e01090.

Zastaprazan (JP-1366, JP1366)

生物&药学活性

物理化学性质&存储条件

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Zastaprazan (JP-1366, JP1366)

生物&药学活性

物理化学性质&存储条件

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